Wirtenberger, Michael and Tchatchou, Sandrine and Hemminki, Kari and Schmutzhard, Julia and Sutter, Christian and Schmutzler, Rita K. and Meindl, Alfons and Wappenschmidt, Barbara and Kiechle, Marion and Arnold, Norbert and Weber, Bernhard H. F. and Niederacher, Dieter and Bartram, Claus R. and Burwinkel, Barbara (2006) Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. Carcinogenesis 27 (11), pp. 2201-2208.
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The mitogen effect of the ovarian steroid estrogen is a strong risk factor for breast cancer development. This effect is mainly mediated by the estrogen receptor alpha, a hormone inducible transcription factor, which activates gene expression through recruiting multiple coactivators, such as PPARGC1A, PPARGC1B and EP300. We tested the hypothesis that non-conservative, putative functional amino ...
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|Institutions:||Medicine > Lehrstuhl für Humangenetik|
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||18 Sep 2007|
|Last Modified:||13 Mar 2014 10:14|