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Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer

Wirtenberger, Michael and Frank, Bernd and Hemminki, Kari and Klaes, Rüdiger and Schmutzler, Rita K. and Wappenschmidt, Barbara and Meindl, Alfons and Kiechle, Marion and Arnold, Norbert and Weber, Bernhard H. F. and Niederacher, Dieter and Bartram, Claus R. and Burwinkel, Barbara (2006) Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer. Carcinogenesis 27 (8), pp. 1655-1660.

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Other URL: http://dx.doi.org/10.1093/carcin/bgi374, http://carcin.oxfordjournals.org/cgi/content/abstract/27/8/1655


Abstract

Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive disorders, Werner and Bloom syndromes, which are associated with premature ageing and cancer predisposition. We tested the hypothesis whether three polymorphic, non-conservative amino acid exchanges in WRN and BLM act as low-penetrance familial breast cancer risk factors. Moreover, we examined the putative ...

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Item Type:Article
Date:August 2006
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1093/carcin/bgi374DOI
16501249PubMed ID
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:18 Sep 2007
Last Modified:13 Mar 2014 10:14
Item ID:2128
Owner Only: item control page
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