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Analysis of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry


URN to cite this document: urn:nbn:de:bvb:355-epub-213956

Stevens, Axel Peter (2011) Analysis of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry. PhD, Universität Regensburg

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Abstract (English)

5’-Deoxy-5’-methylthioadenosine (MTA) is formed in the course of the synthesis of polyamines from S-adenosylmethionine (SAM). Tumors lack the enzyme methylthioadenosine phosphorylase (MTAP), which metabolizes MTA, and should accumulate MTA. In a first step, a method for quantification of MTA by liquid chromatography-mass spectrometry was developed and the postulated accumulation of MTA in tumors ...

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Translation of the abstract (German)

5’-Deoxy-5’-methylthioadenosin (MTA) entsteht im Zuge der Polyaminsynthese aus S-Adenosylmethionin (SAM). Das für den Abbau von MTA nötige Enzym Methylthioadenosinphosphorylase (MTAP) ist in vielen Tumoren nicht vorhanden oder zumindest in seiner Aktivität stark vermindert und somit wird postuliert, dass in Tumoren MTA akkumuliert. Zuerst wurde eine Methode zur quantitativen Bestimmung von MTA ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:5 August 2011
Referee:Prof. Dr. Frank-Michael Matysik and Prof. Dr. Peter Oefner
Date of exam:29 June 2011
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik)
Medicine > Lehrstuhl für Funktionelle Genomik
Research groups and research centres:Not selected
Keywords:5’-Deoxy-5’-methylthioadenosine (MTA), methythioadenosine phosphorylase (MTAP), metabolomics, liquid chromatography-tandem mass spectrometry, methionine and polyamine pathways, Metabolomics, Flüssigchromatographie-Tandemmassenspektrometrie, Methionin- und Polyaminstoffwechselwege
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:05 Aug 2011 08:52
Last Modified:13 Mar 2014 17:42
Item ID:21395
Owner Only: item control page
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