Startseite UB

Ambivalence of drug metabolism: Exploration of cilazapril and candesartan prodrugs for transdermal delivery and search for toxic reactive intermediates of N(G)-acylated hetarylpropylguanidines

URN to cite this document: urn:nbn:de:bvb:355-epub-215664

Ertel, Miriam (2012) Ambivalence of drug metabolism: Exploration of cilazapril and candesartan prodrugs for transdermal delivery and search for toxic reactive intermediates of N(G)-acylated hetarylpropylguanidines. PhD, Universität Regensburg

[img]
Preview
License: Publishing license for publications including print on demand
PDF
Download (16MB)

Abstract (English)

Figuratively, drug metabolism can be considered as two sides of the same coin; one leading to desired, beneficial effects, e.g. by activation of prodrugs, whereas the other one results in adverse side effects due to toxic metabolites. In this work both aspects were explored. Transdermal therapeutic systems (TTS) are known as drug formulations providing constant and sustained drug plasma levels ...

plus

Translation of the abstract (German)

Der Wirkstoffmetabolismus gleicht zwei Seiten einer Medaille. Während die eine zu erwünschten Effekten führt, wie z.B. zur Aktivierung von Prodrugs, resultiert die andere in unerwünschten Nebenwirkungen aufgrund von toxischen Metaboliten. Beide Aspekte werden in dieser Arbeit betrachtet. Transdermale therapeutische Systeme (TTS) bewirken konstante, langanhaltende Blutspiegel bei geringer ...

plus


Export bibliographical data



Item Type:Thesis of the University of Regensburg (PhD)
Date:19 July 2012
Referee:Prof. Dr. Armin Buschauer and Prof. Dr. Günther Bernhardt
Date of exam:15 July 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Research groups and research centres:Not selected
Keywords:Drug metabolism, prodrugs, cilazapril, candesartan, transdermal delivery, transdermal therapeutic system, TTS, skin permeation, toxicity, reactive metabolites, reactive intermediates, trapping reaction, glutathione, LC-MS
Subjects:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:19 Jul 2012 09:00
Last Modified:13 Mar 2014 19:00
Item ID:21566
Owner Only: item control page

Downloads

Downloads per month over past year

  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact