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Nucleosomes protect DNA from DNA methylation in vivo and in vitro

Felle, Max and Hoffmeister, Helen and Rothammer, Julia and Fuchs, Andreas and Exler, Josef H. and Längst, Gernot (2011) Nucleosomes protect DNA from DNA methylation in vivo and in vitro. Nucleic Acids Research 39, p. 6956.

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Positioned nucleosomes limit the access of proteins to DNA. However, the impact of nucleosomes on DNA methylation in vitro and in vivo is poorly understood. Here, we performed a detailed analysis of nucleosome binding and nucleosomal DNA methylation by the de novo methyltransferases. We show that compared to linker DNA, nucleosomal DNA is largely devoid of CpG methylation. ATP-dependent chromatin ...


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Item Type:Article
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst
Projects:Open Access Publizieren (DFG)
Identification Number:
Keywords:Gene Regulation, Chromatin and Epigenetics
Dewey Decimal Classification:500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:26 Jul 2011 08:03
Last Modified:13 Mar 2014 17:47
Item ID:21623
Owner Only: item control page


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