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Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase

Braun, Stephan and Botzki, Alexander and Salmen, Sunnhild and Textor, Christian and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2011) Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase. European Journal of Medicinal Chemistry 46 (9), pp. 4419-4429.

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Abstract

Bacterial hyaluronan lyases (Hyal) degrade hyaluronan, an important component of the extracellular matrix, and are involved in microbial spread. Hyal inhibitors may serve as tools to study the role of the enzyme, its substrates and products in the course of bacterial infections. Moreover, such enzyme inhibitors are potential candidates for antibacterial combination therapy. Based on crystal ...

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Item Type:Article
Date:19 July 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
21803461PubMed ID
10.1016/j.ejmech.2011.07.014DOI
Keywords:Hyaluronan lyase inhibitors; Streptococcus agalactiae; Structure-based design; Benzimidazole-2-thiones; Benzoxazole-2-thiones
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:12 Aug 2011 07:30
Last Modified:18 Nov 2013 13:53
Item ID:21748
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