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Induction of cytolytic T lymphocytes directed towards the V3 loop of the human immunodeficiency virus type 1 external glycoprotein gp120 by p55gag/V3 chimeric vaccinia viruses

Wagner, Ralf and Böltz, T. and Deml, Ludwig and Modrow, Susanne and Wolf, Hans J. (1993) Induction of cytolytic T lymphocytes directed towards the V3 loop of the human immunodeficiency virus type 1 external glycoprotein gp120 by p55gag/V3 chimeric vaccinia viruses. The Journal of general virology 74 (7), pp. 1261-1269.

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Abstract

T cell-mediated cytotoxicity may play an important role in controlling infection by human immunodeficiency virus (HIV). In order to study the ability of rationally designed antigens to induce cytolytic T lymphocytes (CTLs) we replaced stretches of 30 to 50 amino acids at the p17-MA/p24-CA cleavage site, within the p24-CA moiety and within the p6-LI portion of the HIV type 1 p55gag precursor by ...

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Item Type:Article
Date:1993
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
7687647PubMed ID
10.1099/0022-1317-74-7-1261DOI
Classification:
NotationType
AIDS Vaccines/isolation & purificationMESH
Amino Acid SequenceMESH
AnimalsMESH
Antibodies, MonoclonalMESH
Base SequenceMESH
Cell LineMESH
Cytotoxicity, ImmunologicMESH
Epitopes/immunologyMESH
Gene Products, gag/isolation & purificationMESH
Genes, gagMESH
HIV Envelope Protein gp120/isolation & purificationMESH
HIV-1/immunologyMESH
MiceMESH
Mice, Inbred BALB CMESH
Molecular Sequence DataMESH
OligodeoxyribonucleotidesMESH
Recombinant Fusion Proteins/isolation & purificationMESH
T-Lymphocytes, Cytotoxic/immunologyMESH
Vaccinia virus/isolation & purificationMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:12 Aug 2011 08:57
Last Modified:13 Mar 2014 17:49
Item ID:21761
Owner Only: item control page

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