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Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma

Plander, Mark and Ugocsai, Peter and Seegers, Silvia and Orso, Evelyn and Reichle, Albrecht and Schmitz, Gerd and Hofstädter, Ferdinand and Brockhoff, Gero (2011) Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma. Annals of Hematology.

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Other URL: http://www.springerlink.com/content/ru2584446173w32r/


Abstract

The prolonged life span of chronic lymphocytic leukemia (CLL) cells in vivo is assumed to depend on the surrounding microenvironment since this biologic feature is lost in vitro. We studied here the molecular interactions between CLL cells and their surrounding stroma to identify factors that help CLL cells to resist apoptosis. Sorted CLL cells from 21 patients were cultured in vitro on ...

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Item Type:Article
Date:5 April 2011
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1007/s00277-011-1218-zDOI
Keywords:Chronic lymphocytic leukemia – Apoptosis – Stroma – CD49d – IL-8
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Silvia Seegers
Deposited On:17 Aug 2011 07:25
Last Modified:17 Aug 2011 07:25
Item ID:21777
Owner Only: item control page
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