Röher, H. D. and Lorenz, Wilfried and Lennartz, H. and Kusche, J. and Dietz, W. and Gerdes, B. and Parkin, J. V.
Plasma histamine levels in patients in the course of several standard operations: influence of anaesthesia, surgical trauma and blood transfusion.
Klinische Wochenschrift 60 (17), pp. 926-934.
A prospective controlled clinical trial was conducted on changes in plasma histamine and catecholamine levels during 5 standard operations. This communication, as the first part of the trial, deals only with the feasibility of such a trial and the changes in plasma histamine levels. Elevated histamine concentrations corresponding to histamine-release responses of greater than 1 ng/ml occurred in 8 of 25 operations. In an explorative analysis these responses were associated with distinct phases of anaesthesia or the surgical procedure. Blood transfusion carried the risk of infusion of "free histamine" into the patient--especially when administered under pressure. Since during operations "free histamine" enters the circulation with a rather high incidence and may cause harmful effects, premedication with H1-+H2-receptor antagonists seems worth consideration.
|Institutions:|| Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V.|
|Blood Transfusion/adverse effects||MESH|
|Clinical Trials as Topic||MESH|
|Histamine H1 Antagonists/therapeutic use||MESH|
|Histamine H2 Antagonists/therapeutic use||MESH|
|Surgical Procedures, Operative/adverse effects||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||22 Aug 2011 14:05|
|Last Modified:||22 Aug 2011 14:05|