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The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

Felle, Max and Joppien, Saskia and Németh, Attila and Diermeier, Sarah and Thalhammer, Verena and Dobner, Thomas and Kremmer, Elisabeth and Kappler, Roland and Längst, Gernot (2011) The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Research 39, p. 8355.

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Other URL: http://nar.oxfordjournals.org/content/early/2011/07/09/nar.gkr528.abstract


Abstract

Aberrant DNA methylation is often associated with cancer and the formation of tumors; however, the underlying mechanisms, in particular the recruitment and regulation of DNA methyltransferases remain largely unknown. In this study, we identified USP7 as an interaction partner of Dnmt1 and UHRF1 in vivo. Dnmt1 and USP7 formed a soluble dimer complex that associated with UHRF1 as a trimeric complex ...

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Item Type:Article
Date:2011
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1093/nar/gkr528DOI
Keywords:Gene Regulation, Chromatin and Epigenetics
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Universitätsbibliothek Regensburg
Deposited On:31 Aug 2011 10:08
Last Modified:13 Mar 2014 19:59
Item ID:21967
Owner Only: item control page

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