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Understanding tumor heterogeneity as functional compartments--superorganisms revisited

Grunewald, Thomas G. P. and Herbst, Saskia M. and Heinze, Jürgen and Burdach, Stefan (2011) Understanding tumor heterogeneity as functional compartments--superorganisms revisited. Journal of translational medicine 9, p. 79.

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Abstract

Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes."Accordingly, we ...

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Item Type:Article
Date:2011
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
12407407PubMed ID
10.1186/1479-5876-9-79DOI
Classification:
NotationType
AnimalsMESH
Clone CellsMESH
Genetic HeterogeneityMESH
HumansMESH
Immunologic SurveillanceMESH
Insects/physiologyMESH
Neoplasms/pathologyMESH
Neovascularization, Pathologic/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Sep 2011 09:37
Last Modified:13 Mar 2014 18:01
Item ID:22142
Owner Only: item control page

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