Grunewald, Thomas G. P. and Herbst, Saskia M. and Heinze, Jürgen and Burdach, Stefan
Understanding tumor heterogeneity as functional compartments--superorganisms revisited.
Journal of translational medicine 9, p. 79.
Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes."Accordingly, we propose a model in which clonal expansion and cumulative acquisition of genetic alterations produce tumor compartments each equipped with distinct traits and thus distinct functions that cooperate to establish clinically apparent tumors. This functional compartment model also suggests mechanisms for the self-construction of tumor stem cell niches. Thus, thinking of a tumor as a superorganism will provide systemic insight into its functional compartmentalization and may even have clinical implications.
|Institutions:|| Medicine > Lehrstuhl für Humangenetik|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||26 Sep 2011 09:37|
|Last Modified:||26 Sep 2011 09:37|