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A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

Bucher, Joachim and Riedmaier, Stephan and Schnabel, Anke and Marcus, Katrin and Vacun, Gabriele and Weiss, Thomas S. and Thasler, Wolfgang E. and Nüssler, Andreas K. and Zanger, Ulrich M. and Reuss, Matthias (2011) A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes. BMC systems biology 5 (1), p. 66.

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Abstract

A dynamic model for the biotransformation of atorvastatin has been developed using quantitative metabolite measurements in primary human hepatocytes. The model comprises kinetics for transport processes and metabolic enzymes as well as population liver expression data allowing us to assess the impact of inter-individual variability of concentrations of key proteins. Application of computational ...

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Item Type:Article
Date:2011
Institutions:Medicine > Lehrstuhl für Kinder- und Jugendmedizin
Identification Number:
ValueType
15772423PubMed ID
10.1186/1752-0509-5-66DOI
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Sep 2011 09:39
Last Modified:13 Mar 2014 18:02
Item ID:22149
Owner Only: item control page

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