Browse:

The university is member of the Confederation of Open Access Repositories (COAR)

More information about Open Acces at open-acces.net

Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

Hackl, Christina and Lang, Sven A. and Moser, Christian and Mori, Akira and Fichtner-Feigl, Stefan and Hellerbrand, Claus and Dietmeier, Wolfgang and Schlitt, Hans J. and Geissler, Edward K. and Stoeltzing, Oliver (2010) Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. BMC cancer 10, p. 668.

Preview

PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
935Kb

Abstract

In conclusion, ATF3 down-regulation in colon cancer promotes tumor growth and metastasis. Considering that blocking Hsp90 induces ATF3 expression, Hsp90 inhibition may represent a valid strategy to treat metastatic colon cancer by up-regulating this anti-metastatic transcription factor.

Item Type:

Article

Institutions:

Medicine > Lehrstuhl für Chirurgie

Identification Number:

Value	Type
21129190	PubMed ID
10.1186/1471-2407-10-668	DOI

Classification:

Notation	Type
Activating Transcription Factor 3/metabolism	MESH
Animals	MESH
Antineoplastic Agents/pharmacology	MESH
Benzoquinones/pharmacology	MESH
Cell Movement/drug effects	MESH
Colonic Neoplasms/pathology	MESH
HCT116 Cells	MESH
HSP90 Heat-Shock Proteins/metabolism	MESH
Humans	MESH
Lactams, Macrocyclic/pharmacology	MESH
Liver Neoplasms/secondary	MESH
Male	MESH
Mice	MESH
Mice, Nude	MESH
Neoplasm Invasiveness	MESH
Peritoneal Neoplasms/secondary	MESH
RNA Interference	MESH
Time Factors	MESH
Transfection	MESH
Tumor Burden/drug effects	MESH
Up-Regulation	MESH