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Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

Hackl, Christina and Lang, Sven A. and Moser, Christian and Mori, Akira and Fichtner-Feigl, Stefan and Hellerbrand, Claus and Dietmeier, Wolfgang and Schlitt, Hans J. and Geissler, Edward K. and Stoeltzing, Oliver (2010) Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. BMC cancer 10, p. 668.

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Abstract

In conclusion, ATF3 down-regulation in colon cancer promotes tumor growth and metastasis. Considering that blocking Hsp90 induces ATF3 expression, Hsp90 inhibition may represent a valid strategy to treat metastatic colon cancer by up-regulating this anti-metastatic transcription ...

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Item Type:Article
Date:2010
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
21129190PubMed ID
10.1186/1471-2407-10-668DOI
Classification:
NotationType
Activating Transcription Factor 3/metabolismMESH
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Benzoquinones/pharmacologyMESH
Cell Movement/drug effectsMESH
Colonic Neoplasms/pathologyMESH
HCT116 CellsMESH
HSP90 Heat-Shock Proteins/metabolismMESH
HumansMESH
Lactams, Macrocyclic/pharmacologyMESH
Liver Neoplasms/secondaryMESH
MaleMESH
MiceMESH
Mice, NudeMESH
Neoplasm InvasivenessMESH
Peritoneal Neoplasms/secondaryMESH
RNA InterferenceMESH
Time FactorsMESH
TransfectionMESH
Tumor Burden/drug effectsMESH
Up-RegulationMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Sep 2011 09:44
Last Modified:13 Mar 2014 18:02
Item ID:22188
Owner Only: item control page
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