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Highly potent and selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships of mono- and bivalent ligands

URN to cite this document: urn:nbn:de:bvb:355-epub-222378

Birnkammer, Tobias (2011) Highly potent and selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships of mono- and bivalent ligands. PhD, Universität Regensburg

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Abstract (English)

Potent and selective histamine H2 receptor (H2R) agonists, including brain-penetrating compounds, are required as pharmacological tools to evaluate the (patho)physiological role of H2Rs. Moreover, H2R agonists might be of therapeutic value as drugs, for example, in the treatment of acute myelogenous leukemia. Previously, acylguanidine-type H2R agonists with reduced basicity were synthesized in ...

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Translation of the abstract (German)

Selektive Histamin H2-Rezeptor-Agonisten rücken, u.a. aufgrund ihres Einflusses auf Leukämiezellen und der möglichen neuropharmakologischen Wirkung, immer mehr in den Fokus. Bereits in den letzten Jahrzehnten wurden zahlreiche H2R-Agonisten wie 5-Methylhistamin, Dimaprit, Impromidin und Arpromidin beschrieben. Nach der Entdeckung der H3 und H4 Rezeptoren wurde jedoch deren H2R-Selektivität ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:20 October 2011
Referee:Prof. Dr. Armin Buschauer and Prof. Dr. Sigurd Elz
Date of exam:13 October 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:medicinal chemistry, histamine H2 receptor, acylguanidine, bivalent ligand
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Oct 2011 09:00
Last Modified:13 Mar 2014 18:03
Item ID:22237
Owner Only: item control page
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