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Synthese und pharmakologische Charakterisierung dualer Histamin-H1-/H4-Rezeptorliganden

URN to cite this document: urn:nbn:de:bvb:355-epub-224300

Wagner, Eva (2012) Synthese und pharmakologische Charakterisierung dualer Histamin-H1-/H4-Rezeptorliganden. PhD, Universität Regensburg.

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Abstract (German)

Im Rahmen dieses Promotionsprojektes sollten duale H1-/H4-Rezeptor-Antagonisten entwickelt werden. Der im Jahr 2000 entdeckte H4-Rezeptor spielt wie der H1-Rezeptor eine Rolle in der Pathogenese von allergischen Krankheiten[1]. Ausschlaggebend für diese Arbeit waren die Ergebnisse der Neumann-Forschungsgruppe[2]: es wurde gezeigt, dass die kombinierte Gabe von H1-Rezeptorantagonist (Mepyramin) ...


Translation of the abstract (English)

In literature, a synergism between histamine H1 and H4 receptor is discussed[1]. Furthermore, it was shown, that the combined application of mepyramine, a H1 antagonist and JNJ7777120, a H4 receptor ligand leads to a synergistic effect in the acute murine asthma model[2]. Thus, the aim of this project was to develop new hybrid ligands, containing one H1 and one H4 pharmacophor, in order to ...


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Item type:Thesis of the University of Regensburg (PhD)
Referee:Prof. Dr. Sigurd Elz
Date of exam:14 October 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Keywords:Histamin-H1-Rezeptor, Histamin-H4-Rezeptor, Meypramin, JNJ7777120, Astemizol, Hybridverbindungen Histamine H1 receptor, Histamine H4 receptor, Meypramine, JNJ7777120, Astemizole, hybrid compounds
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:05 Nov 2012 07:39
Last modified:13 Mar 2014 19:21
Item ID:22430
Owner only: item control page


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