Kraus, J. and Blaschek, W. and Schütz, M. and Franz, Gerhard (1992) Antitumor Activity of Cell Wall β-1,3/1,6-Glucans from Phytophthora Species. Planta Medica 58, pp. 39-45.
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From the cell walls of various Phytophthora species (Oomycetes) different water-soluble β-1,3/1,6-glucans were isolated and characterized. The glucans with relative molecular masses between 13 and 50 kd exhibited varying degrees of branching in the β-1,3-linked glucan backbone ranging from 14 to 50%. The dose-dependent antitumor activity of the glucans against allogeneic sarcoma-180 was investigated. It could be demonstrated that β-1, 3/1,6-glucans with relative molecular masses below 50 kd can exhibit a prominent antitumor activity (inhibition rate up to 99%), being comparable to that of the high relative molecular mass (450 kd) β-1,3/1,6-glucans. Biological activity of the glucans could be shown to be correlated with a low degree of branching. The most potent glucan with a degree of branching of 14 % also was active against the syngeneic DBA/2-MC.SC-1 fibrosarcoma (inhibition rate up to 90%) and in combination with a suboptimum dose of diethylstilbestrol against Noble-Nb prostate carcinoma (inhibition rate up to 90%).
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz|
|Keywords:||Phytophthora - cell wall glucans - β-1,3/1,6-glucans - antitumor activity - sarcoma-180 - Noble-Nb prostate carcinoma - DBA/2-MC.SC-1 fibrosarcoma|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
500 Science > 570 Life sciences
|Created at the University of Regensburg:||Unknown|
|Deposited On:||09 Nov 2011 10:52|
|Last Modified:||09 Nov 2011 10:52|
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