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Antiviral and Anticoagulant Activities of a Water-Soluble Fraction of the Marine Diatom Haslea ostrearia

Bergé, J.-P. and Bourgougnon, N. and Alban, S. and Pojer, F. and Billaudel, S. and Chermann, J.-C. and Robert, J. M. and Franz, Gerhard (1999) Antiviral and Anticoagulant Activities of a Water-Soluble Fraction of the Marine Diatom Haslea ostrearia. Planta Medica 65, pp. 604-609.

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Abstract

A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50 % inhibitory concentration (EC50) of 14 μg/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation on MT4 cells. At concentrations up to 200 μg/ml, no cytotoxicity was observed for both ...

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Item Type:Article
Date:1999
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz
Identification Number:
ValueType
10.1055/s-1999-14032DOI
Keywords:Diatom, Haslea ostrearia - Naviculaceae - pennate, anti-HSV-1 activity - anti-HIV-1 activity - anticoagulant activity
Subjects:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:09 Nov 2011 09:48
Last Modified:09 Nov 2011 09:48
Item ID:22532
Owner Only: item control page
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