Bergé, J.-P. and Bourgougnon, N. and Alban, S. and Pojer, F. and Billaudel, S. and Chermann, J.-C. and Robert, J. M. and Franz, Gerhard (1999) Antiviral and Anticoagulant Activities of a Water-Soluble Fraction of the Marine Diatom Haslea ostrearia. Planta Medica 65, pp. 604-609.
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A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50 % inhibitory concentration (EC50) of 14 μg/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation on MT4 cells. At concentrations up to 200 μg/ml, no cytotoxicity was observed for both the Vero and MT4 cells. The fraction only inhibited the blood coagulation process at concentrations considerably exceeding the EC50.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz|
|Keywords:||Diatom, Haslea ostrearia - Naviculaceae - pennate, anti-HSV-1 activity - anti-HIV-1 activity - anticoagulant activity|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
500 Science > 570 Life sciences
|Created at the University of Regensburg:||Unknown|
|Deposited On:||09 Nov 2011 09:48|
|Last Modified:||09 Nov 2011 09:48|