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Biochemical and functional studies on mouse ficolin-B, a novel pattern recognition molecule of the innate immune system

URN to cite this document: urn:nbn:de:bvb:355-epub-225621

Elumalai, Preetham (2011) Biochemical and functional studies on mouse ficolin-B, a novel pattern recognition molecule of the innate immune system. PhD, Universität Regensburg

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Abstract (English)

Ficolins are members of the collectin family of proteins which in human and mice are able to recognize pathogen associated molecular patterns (PAMPs) on microbial surfaces. Ficolins trigger the activation of the innate immune system by initiating the complement cascade in serum upon binding to their specific PAMPs. Our group recently published the first observation on the cellular localization of ...

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Translation of the abstract (German)

Ficoline sind Mitglieder der Collectin-Proteinfamilie, die in Mensch und Maus Pathogen-assoziierte molekulare Muster (PAMP) auf Oberflächen erkennen. Ficoline starten das angeborene Immunsystem, indem sie im Serum nach Bindung an spezifische PAMP die Complement-Kaskade aktivieren. Unsere Arbeitsgruppe zeigte als erste, dass Maus-Ficolin-B intrazellulär lokalisiert ist. Im Gegensatz zum humanen ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:16 November 2011
Referee:Prof. Dr. Jörg Heilmann
Date of exam:10 November 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Keywords: Complement system, Ficolin, Innate immunity, Lectin pathway
Subjects:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:16 Nov 2011 10:02
Last Modified:13 Mar 2014 18:10
Item ID:22562
Owner Only: item control page
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