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Adult neurogenesis in transgenic animal models of DYT1 primary torsion dystonia

URN to cite this document: urn:nbn:de:bvb:355-epub-225973

Regensburger, Martin (2011) Adult neurogenesis in transgenic animal models of DYT1 primary torsion dystonia. PhD, Universität Regensburg.

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Abstract (English)

Primary torsion dystonia is a hereditary movement disorder characterized by generalized, sustained, involuntary muscle contractions with an underlying three-base-pair deletion in the DYT1 gene coding for torsinA. The precise role of torsinA and the effect of its mutated form remain unclear to date, but its functions have been linked to chaperones, secretory cellular mechanisms, dopaminergic ...


Translation of the abstract (German)

Die primäre Torsionsdystonie ist eine erbliche Bewegungsstörung, bei der es aufgrund einer 3-Basenpaar-Deletion im DYT1-Gen zu generalisierten, unwillkürlichen und anhaltenden Muskelkontraktionen kommt. Die exakte Rolle des Genprodukts TorsinA und dessen mutierter Form ist noch immer unbekannt, aber dessen Funktion wurde mit Chaperonen, sekretorischen Zellmechanismen, dem Dopaminstoffwechsel und ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:22 November 2011
Referee:PD Dr. Beate Winner and Prof. Dr. Andreas Luchner
Date of exam:17 November 2011
Institutions:Medicine > Lehrstuhl für Neurologie
Keywords:bromodeoxyuridine, cellular plasticity, doublecortin, dystonia, DYT1, hippocampus, olfactory bulb, subventricular zone, torsinA
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:22 Nov 2011 09:52
Last modified:13 Mar 2014 18:11
Item ID:22597
Owner only: item control page


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