Browse:

The university is member of the Confederation of Open Access Repositories (COAR)

More information about Open Acces at open-acces.net

Sulfated β-(1→4)-galacto-oligosaccharides and their effect on angiogenesis

Käsbauer, C. W. and Paper, D. H. and Franz, Gerhard (2001) Sulfated β-(1→4)-galacto-oligosaccharides and their effect on angiogenesis. Carbohydrate research 330 (3), pp. 427-430.

Full text not available from this repository.

Abstract

Sulfated β-(1→4)-galacto-oligosaccharides were prepared from an arabino-galacto-rhamno-galacturonan from Lupinus polyphyllus Lindl. by successive partial hydrolysis and SO3–pyridine sulfation in DMF. The resulting oligosaccharide polysulfates were analyzed by analytical GPC and the sulfate content was determined by ion chromatography. DP 5 and higher showed a pronounced antiangiogenic effect with scores of 0.9–1.2 for DP 7–9 using the CAM-assay. An interaction with the fibroblast growth factor FGF-2 was noticed for DP 4–12 depending on the degree of sulfation using the FGF-2-trypsin assay.

Item Type:

Article

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz

Identification Number:

Value	Type
11270823	PubMed ID

Classification:

Notation	Type
Allantois/blood supply	MESH
Angiogenesis Inhibitors/pharmacology	MESH
Animals	MESH
Carbohydrate Conformation	MESH
Carbohydrate Sequence	MESH
Chick Embryo	MESH
Chorion/blood supply	MESH
Fabaceae/chemistry	MESH
Molecular Sequence Data	MESH
Neovascularization, Physiologic/drug effects	MESH
Oligosaccharides/pharmacology	MESH
Plants, Medicinal	MESH
Polysaccharides/isolation & purification	MESH