Paper, D. and Franz, Gerhard (1990) Biotransformation of 5βH-pregnan-3βol-20-one and cardenolides in cell suspension cultures of Nerium oleander L. Plant Cell Reports 8, pp. 651-655.
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In order to demonstrate enzyme activities playing a role in the biosynthesis of cardenolides and 2,6-dideoxysugars, 5betaH-pregnan-3betaol-20-one and cardenolides (digitoxigenin, oleandrigenin/L-oleandrose, oleandrin, neriifolin, digitoxigeninmonodigitoxoside and strospeside) were fed to cell suspension cultures of Nerium oleander L.. It could be shown that cell suspension cultures of Nerium oleander L. are able to oxidize, isomerize and glucosylate 5betaH-steroidaglycones at C-3. The respective glucosides of the 5betaH-steroid-aglycones are the main biotransformation products. These cell cultures are an appropriate tool for the production of labelled 5betaH-steroidglucosides.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||22 Nov 2011 12:54|
|Last Modified:||22 Nov 2011 12:54|