Aouadi, S. and Heyraud, A. and Seigle-Murandi, F. and Steinmann, R. and Kraus, J. and Franz, Gerhard (1991) Structure and properties of an extracellular polysaccharide from Laetisaria arvalis. Evaluation of its antitumour activity. Carbohydrate Polymers 16, pp. 155-160.
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A polysaccharide isolated from the culture filtrate of Laetisaria arvalis (Basidiomycete) has been submitted to acid hydrolysis, periodate oxidation, Smith degradation, methylation analysis, and treatment with endo-(1 → 3)-β-D-glucanase. A 6-O-branched (1 → 3)-β-D-glucan with a structure similar to that of scleroglucan has been identified. In aqueous solution, this polysaccharide develops high viscosities and shows pseudoplastic behaviour. Increasing NaOH concentration reduces viscosity, which is due to a similar conformational transition to that found for scleroglucan.
The antitumour activity of the glucan was tested against solid Sarcoma-180 in mice. The polysaccharide strongly inhibited tumour growth with an inhibition ratio of almost 100%.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||28 Nov 2011 09:25|
|Last Modified:||28 Nov 2011 09:25|
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