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Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocytopenia

Greinacher, A. and Alban, S. and Dummel, V. and Franz, Gerhard and Mueller-Eckhardt, C. (1995) Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocytopenia. Thrombosis and haemostasis 74 (3), pp. 886-892.

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Abstract

HAT is the most frequent drug induced immune-thrombocytopenia. We recently identified multimolecular PF4/heparin complexes as the major antigen. In order to evaluate the structural requirements for formation of the antigenic complex, we chemically synthesized 13 glucan sulfates and used 5 heparin fractions (2.4-4.8 kD) and a synthesized pentasaccharide, representing the antithrombin III binding ...

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Item Type:Article
Date:1995
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz
Identification Number:
ValueType
8571316PubMed ID
Classification:
NotationType
Anticoagulants/chemistryMESH
Antigens/biosynthesisMESH
Carbohydrate ConformationMESH
Carbohydrates/chemistryMESH
Case-Control StudiesMESH
Glucans/chemistryMESH
Heparin/adverse effectsMESH
HumansMESH
Molecular StructureMESH
Molecular WeightMESH
Oligosaccharides/immunologyMESH
Risk FactorsMESH
Thrombocytopenia/immunologyMESH
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:30 Nov 2011 08:51
Last Modified:30 Nov 2011 08:51
Item ID:22802
Owner Only: item control page
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