Greinacher, A. and Alban, S. and Dummel, V. and Franz, Gerhard and Mueller-Eckhardt, C. (1995) Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocytopenia. Thrombosis and haemostasis 74 (3), pp. 886-892.
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HAT is the most frequent drug induced immune-thrombocytopenia. We recently identified multimolecular PF4/heparin complexes as the major antigen. In order to evaluate the structural requirements for formation of the antigenic complex, we chemically synthesized 13 glucan sulfates and used 5 heparin fractions (2.4-4.8 kD) and a synthesized pentasaccharide, representing the antithrombin III binding ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz|
|Dewey Decimal Classification:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||30 Nov 2011 08:51|
|Last Modified:||30 Nov 2011 08:51|