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Pharmacokinetic and pharmacodynamic characterization of a medium-molecular-weight heparin in comparison with UFH and LMWH

Alban, Susanne and Welzel, Dieter and Hemker, H Coenraad (2002) Pharmacokinetic and pharmacodynamic characterization of a medium-molecular-weight heparin in comparison with UFH and LMWH. Seminars in thrombosis and hemostasis 28 (4), pp. 369-378.

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Abstract

Despite the well-established medical use of heparins, the question arises whether the efficacy-safety ratio of the available heparins can still be improved. Therefore, a medium-molecular-weight heparin (MMWH), a new heparin with an average molecular weight of 10.5 kDa and a narrow molecular weight range (9.5 to 11.5 kDa) was developed. Its in vitro activities amount to 174.9 anti-factor Xa (aXa) ...

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Item Type:Article
Date:2002
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Franz
Identification Number:
ValueType
12244484PubMed ID
10.1055/s-2002-34306DOI
Classification:
NotationType
AdultMESH
Antithrombin III/antagonists & inhibitorsMESH
Cross-Over StudiesMESH
Double-Blind MethodMESH
Enoxaparin/pharmacokineticsMESH
Factor Xa/antagonists & inhibitorsMESH
Heparin/pharmacokineticsMESH
Heparin, Low-Molecular-Weight/pharmacokineticsMESH
HumansMESH
MaleMESH
Molecular WeightMESH
Partial Thromboplastin TimeMESH
PharmacokineticsMESH
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:01 Dec 2011 08:44
Last Modified:01 Dec 2011 08:44
Item ID:22822
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