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Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships

URN to cite this document: urn:nbn:de:bvb:355-epub-229588

Geyer, Roland (2011) Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships. PhD, Universität Regensburg

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Abstract (English)

The recently discovered histamine H4 receptor (H4R) is reported to be involved in immunological processes and inflammatory diseases. However, the (patho)physiological role of the H4R is far from being fully understood. Controversial data on H4R agonists as well as reports on β-arrestin-mediated signaling and partial agonistic effects of the standard H4R antagonist JNJ-7777120 at certain H4R ...

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Translation of the abstract (German)

Der kürzlich entdeckte Histamin H4-Rezeptor (H4R) scheint eine entscheidende Rolle in immunologischen und entzündungsrelevanten Prozessen zu spielen. Allerdings ist die (patho)physiologische Rolle des H4R bei weitem nicht vollständig verstanden. Widersprüchliche Daten über H4R Agonisten sowie Berichte über β-Arrestin-vermittelte Signalwege und partialagonistische Wirkung des H4R Antagonisten ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:14 December 2011
Referee:Prof. Dr. Armin Buschauer and Prof. Dr. Sigurd Elz
Date of exam:8 December 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Research groups and research centres:Not selected
Keywords:Histaminrezeptor, Wirkstoff-Rezeptor-Bindung, H4-Rezeptor, Agonist, Antagonist, Guanidinderivate, Bioisostere, Rigidisierung, Struktur-Aktivitäts-Beziehung, Histamin, H3-Rezeptor, Cyanoguanidin, UR-PI376, OUP-16, UR-RG98, H4-receptor, H3-receptor, cyanoguanidine, chiral HPLC, fluorescent ligand, GTPyS, GPCR, bioisosteric replacement
Subjects:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Dec 2011 09:47
Last Modified:13 Mar 2014 18:17
Item ID:22958
Owner Only: item control page
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