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Modeling molecular signaling and gene expression using Dynamic Nested Effects Models

URN to cite this document: urn:nbn:de:bvb:355-epub-229962

Anchang, Benedict Nchang (2011) Modeling molecular signaling and gene expression using Dynamic Nested Effects Models. PhD, Universität Regensburg.

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Abstract (English)

Cellular decision making in differentiation, proliferation or apoptosis is mediated by molecular signaling processes, which control the regulation and expression of genes. Vice versa, the expression of genes can trigger the activity of signaling pathways. I summarize methodology by Markowetz et al. known as the Nested Effects Models (NEMs) to reconstruct static non-transcriptional networks using ...


Translation of the abstract (German)

Die zelluläre Entscheidungsfindung in der Differenzierung, der Zellproliferation oder der Apoptose wird durch molekulare Signalprozesse, die die Genregulation und -expression steuern, vermittelt. Andersherum kann die Genexpression die Aktivität der Signalverläufe auslösen. Ich fasse die Methodik von Markowetz et al., bekannt als Nested Effects Models (NEMs), zusammen um statische ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:20 December 2011
Referee:Prof. Dr. Rainer Spang and Prof. Dr. Wolfram Gronwald
Date of exam:9 December 2011
Institutions:Biology, Preclinical Medicine
Keywords:Network reconstruction, Dynamic Nested Effects Models
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 510 Mathematics
500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:20 Dec 2011 09:53
Last modified:13 Mar 2014 18:18
Item ID:22996
Owner only: item control page


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