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Einfluss von Pantoprazol auf die Bioverfügbarkeit von Mycophenolsäure aus CellCept® bzw. myfortic®: Pharmakokinetische Untersuchungen in vitro und an Probanden

URN to cite this document: urn:nbn:de:bvb:355-epub-230371

Rupprecht, Korbinian (2012) Einfluss von Pantoprazol auf die Bioverfügbarkeit von Mycophenolsäure aus CellCept® bzw. myfortic®: Pharmakokinetische Untersuchungen in vitro und an Probanden. PhD, Universität Regensburg

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Abstract (German)

In zwei cross-over Studien an gesunden Probanden wurde die Bioverfügbarkeit von Mycophenolsäure und seines Hauptmetaboliten Mycophenolsäure-Glucuronid nach oraler Applikation von Mycophenolat-Mofetil (CellCept®) bzw. Mycophenolat-Natrium (myfortic®) unter gleich- zeitiger Therapie mit einem Protonenpumpenhemmer (Pantozol®) im Vergleich zur jeweils alleinigen Einnahme bestimmt. Nach Einnahme ...


Translation of the abstract (English)

In two cross-over studies on healthy volunteers we investigated the bioavailability of Mycophenolic Acid and its main metabolite Mycophenolic Acid Glucuronide after oral administration of Mycophenolate Mofetil (Cellcept®) or enteric coated Mycophenolate Sodium (myfortic®) with and without co-medication of Pantozol®. After the intake of CellCept® the C(max) of Mycophenolic Acid was divided in ...


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Item Type:Thesis of the University of Regensburg (PhD)
Date:11 January 2012
Referee:Prof. Dr. Michael Bucher and Prof. Dr. Frieder Kees
Date of exam:23 December 2011
Additional information (public):Aus dieser und ergänzenden Arbeiten gingen folgende Publikationen hervor: Rupprecht K., Schmidt, C., Raspe, A., Schweda, F., Shipkova, M., Fischer, et al. (2009) Bioavailability of mycophenolate mofetil and enteric-coated mycophenolate sodium is differentially affected by pantoprazole in healthy volunteers. Journal of Clinical Pharmacology, 49(10), 1196-201 Rupprecht, K., Kees F., Bucher M., Kreuzeder J., Faerber L. (2010) [Sa649] The impact of pH on the solubility of mycophenolate mofetil compared to enteric-coated mycophenolate sodium. NDT Plus, 3 (Suppl 3), iii261 Kees F., Rupprecht K., Moritz S., Steinke T., Bucher M., Faerber L. (2010) [SA-FC447] The influence of co-administered omeprazole on the bioavailability of mycophenolate mofetil (MMF) in healthy volunteers. Journal of the American Society of Nephrology, 21, Supplement, 102A M. G. Kees, T. Steinke, S. Moritz, K. Rupprecht, E. M. Paulus, F. Kees, et al. (2011) Omeprazole impairs the absorption of mycophenolate mofetil but not of enteric-coated mycophenolate sodium in healthy volunteers. Journal of Clinical Pharmacology, epub ahead of print (2011 Sep 8)
Institutions:Medicine > Lehrstuhl für Anästhesiologie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Research groups and research centres:Not selected
Keywords:Mycophenolic Acid, Mycophenolate Mofetil, enteric coated Mycophenolate Sodium, Cellcept®, myfortic®, Pantoprazole, PPI, bioavailability, drug-drug interaction, therapeutic drug monitoring, pharmacokinetics, High Performance Liquid Chromatography
Subjects:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:11 Jan 2012 11:51
Last Modified:13 Mar 2014 18:22
Item ID:23037
Owner Only: item control page


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