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In silico analysis of the histaprodifen induced pathway of the guinea-pig histamine H1 receptor

Strasser, Andrea and Wittmann, Hans-Joachim (2010) In silico analysis of the histaprodifen induced pathway of the guinea-pig histamine H1 receptor. Journal of computer- aided molecular design : J Comput Aided Mol Des 24, pp. 759-769.

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Abstract

The binding of (partial) agonists in the binding pocket of biogenic amine receptors induces a conformational change from the inactive to the active state of the receptors. There is only little knowledge about the binding pathways of ligands into binding pocket on molecular level. So far, it was not possible with molecular dynamic simulations to observe the ligand binding and receptor activation. ...

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Item Type:Article
Date:2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1007/s10822-010-9372-2DOI
Related URLs:
URLURL Type
http://www.springerlink.com/content/b5l31625241w6q54/Publisher
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Andrea Strasser
Deposited On:10 Jan 2012 10:35
Last Modified:10 Jan 2012 10:35
Item ID:23073
Owner Only: item control page
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