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Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production.

Krautwurst, D. and Seifert, Roland and Hescheler, J. and Schultz, Günter (1992) Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production. The Biochemical journal 288 ( Pt 3, pp. 1025-1035.

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Abstract

In human neutrophils, the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) induces increases in the intracellular free Ca2+ concentration ([Ca2+]i) with subsequent activation of beta-glucuronidase release and superoxide (O2-) production. Results from several laboratories suggest that the increase in [Ca2+]i is due to activation of non-selective cation (NSC) channels. We ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
283425PubMed ID
Classification:
NotationType
Adenosine Triphosphate/pharmacologyMESH
Bucladesine/pharmacologyMESH
Calcium/physiologyMESH
Calcium Channels/physiologyMESH
Cell Differentiation/drug effectsMESH
Enzyme ActivationMESH
FluorescenceMESH
Fura-2MESH
GTP-Binding Proteins/physiologyMESH
Glucuronidase/secretionMESH
HumansMESH
Intracellular Fluid/metabolismMESH
Ion Channels/physiologyMESH
Leukemia, Myeloid/pathologyMESH
Manganese/metabolismMESH
Membrane Potentials/physiologyMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Sodium/physiologyMESH
Sodium Channels/physiologyMESH
Stimulation, ChemicalMESH
Superoxides/metabolismMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:23 Jan 2012 12:57
Last Modified:13 Mar 2014 18:28
Item ID:23218
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