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Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism

Ervens, J. and Seifert, Roland (1992) Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism. Biochemical pharmacology 44 (4), pp. 637-644.

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Abstract

3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. Its prodrug, molsidomine (SIN-10), does not release NO but does modulate various cell functions. These findings prompted us to study the effects of SIN-10 and SIN-1 on the respiratory burst in human neutrophils. SIN-10 was more effective than SIN-1 in ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
1324680PubMed ID
Classification:
NotationType
Acetic AcidMESH
Acetic Acids/pharmacologyMESH
Calcium/metabolismMESH
Cell Membrane/metabolismMESH
Cell-Free SystemMESH
Cytosol/metabolismMESH
Dose-Response Relationship, DrugMESH
Drug InteractionsMESH
GTP Phosphohydrolases/metabolismMESH
HumansMESH
Molsidomine/pharmacologyMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Neutrophils/metabolismMESH
Nitric OxideMESH
Oxygen Consumption/drug effectsMESH
Respiratory Burst/drug effectsMESH
Superoxides/metabolismMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:24 Jan 2012 07:55
Last Modified:13 Mar 2014 18:28
Item ID:23219
Owner Only: item control page

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