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Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation

Seifert, Roland and Serke, S. and Huhn, D. and Bessler, W. G. and Hauschildt, S. and Metzger, J. and Wismüller, K. H. and Jung, G. (1992) Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation. European journal of biochemistry / FEBS 203 (1-2), pp. 143-151.

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Abstract

In human neutrophils, the synthetic lipopeptide, N-palmitoyl-S-[2,3- bis(palmitoyloxy-(2RS)-propyl]-(R)-cysteinyl-(S)-seryl-(S)-lysyl-( S)-lysyl-(S) -lysyl-(S)-lysine [Pam3CysSer(Lys)4], activates NADPH-oxidase catalyzed superoxide (O2-) formation through pertussis-toxin-sensitive and pertussis-toxin-insensitive mechanisms (Seifert, R., Schultz, G., Richter-Freund, M., Metzger, J., Wiesmüller, ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
1309696PubMed ID
Classification:
NotationType
Bucladesine/pharmacologyMESH
Calcitriol/pharmacologyMESH
Cell DifferentiationMESH
Dimethyl Sulfoxide/pharmacologyMESH
Flow CytometryMESH
GTP Phosphohydrolases/metabolismMESH
HumansMESH
Interferon-gamma/pharmacologyMESH
Leukemia/pathologyMESH
Lipoproteins/pharmacologyMESH
Pertussis ToxinMESH
Superoxides/metabolismMESH
Transferrin/metabolismMESH
Tretinoin/pharmacologyMESH
Tumor Cells, CulturedMESH
Tumor Necrosis Factor-alpha/pharmacologyMESH
Virulence Factors, Bordetella/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:24 Jan 2012 08:12
Last Modified:13 Mar 2014 18:29
Item ID:23223
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