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The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins

Schwaner, I. and Seifert, Roland and Schultz, Günter (1992) The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins. Eicosanoids 5 Suppl, S10-512.

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Abstract

In the human erythroleukemia cell line, HEL, prostaglandin E2 (PGE2) and the stable prostacyclin analogue, iloprost, increase cytosolic Ca2+ concentration ([Ca2+]i) via pertussis toxin-sensitive and -insensitive pathways. Unlike iloprost, the stable prostacyclin analogue cicaprost (ZK 96480), is devoid of agonistic properties at prostaglandin E2 receptors. We compared the effects of cicaprost, ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
1280455PubMed ID
Classification:
NotationType
Calcium/metabolismMESH
Cytosol/metabolismMESH
Dinoprostone/pharmacologyMESH
Epoprostenol/pharmacologyMESH
GTP-Binding Proteins/physiologyMESH
HumansMESH
Iloprost/pharmacologyMESH
KineticsMESH
Leukemia, Erythroblastic, Acute/metabolismMESH
Pertussis ToxinMESH
Tumor Cells, CulturedMESH
Virulence Factors, Bordetella/pharmacologyMESH
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Gertraud Kellers
Deposited On:24 Jan 2012 08:15
Last Modified:24 Jan 2012 12:55
Item ID:23224
Owner Only: item control page
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