Brandl, Ferdinand and Hammer, Nadine and Blunk, Torsten and Teßmar, Jörg and Göpferich, Achim (2010) Biodegradable hydrogels for time-controlled release of tethered peptides or proteins. Biomacromolecules 11 (2), pp. 496-504.
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Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization of branched poly(ethylene glycol). The gel strength ranged from 1075 to 2435 Pa; the degradation time varied between 24 and 120 h. Fluorescence recovery after photobleaching showed that fluorescently labeled bovine serum albumin (FITC-BSA) was successfully bound to the gel network during gel formation. Within 168 h, the mobility of the tethered molecules gradually increased due to polymer degradation. Using FITC-BSA and lysozyme as model proteins, we showed the potential of the developed hydrogels for time-controlled release. The obtained release profiles had a sigmoidal shape and matched the degradation profile very well; protein release was complete after 96 h.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
600 Technology > 615 Pharmacy
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Owner:||Dr. Ferdinand Brandl|
|Deposited On:||23 Jan 2012 14:17|
|Last Modified:||23 Jan 2012 14:17|