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Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides

Seifert, Roland and Schultz, Günter and Richter-Freund, M. and Metzger, J. and Wiesmüller, K. H. and Jung, G. and Bessler, W. G. and Hauschildt, S. (1990) Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. The Biochemical journal 267 (3), pp. 795-802.

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Abstract

Upon exposure to the bacterial chemotactic peptide fMet-Leu-Phe, human neutrophils release lysozyme and generate superoxide anions (O2.-). The synthetic lipoamino acid N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteine (Pam3Cys), which is derived from the N-terminus of bacterial lipoprotein, when attached to Ser-(Lys)4 [giving Pam3Cys-Ser-(Lys)4], activated O2.- formation and ...

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Item Type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
2160237PubMed ID
Classification:
NotationType
Dose-Response Relationship, DrugMESH
Drug SynergismMESH
Exocytosis/drug effectsMESH
GTP-Binding Proteins/physiologyMESH
HumansMESH
Lipoproteins/pharmacologyMESH
Muramidase/secretionMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Neutrophils/metabolismMESH
Oligopeptides/pharmacologyMESH
Platelet Activating Factor/pharmacologyMESH
Structure-Activity RelationshipMESH
Superoxides/metabolismMESH
Tumor Necrosis Factor-alpha/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:24 Jan 2012 13:38
Last Modified:13 Mar 2014 18:29
Item ID:23244
Owner Only: item control page

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