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Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides

Seifert, Roland and Burde, R. and Schultz, Günter (1989) Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides. The Biochemical journal 259 (3), pp. 813-819.

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Abstract

Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe). In dibutyryl cyclic AMP-differentiated HL-60 cells, ATP and UTP in the presence of cytochalasin B activated O2- formation with EC50 values of 5 microM and efficacies amounting to ...

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Item Type:Article
Date:1989
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
2543370PubMed ID
Classification:
NotationType
Adenosine Triphosphate/pharmacologyMESH
BucladesineMESH
Enzyme Activation/drug effectsMESH
GTP-Binding Proteins/physiologyMESH
HumansMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
NADH, NADPH Oxidoreductases/metabolismMESH
NADPH OxidaseMESH
Neutrophils/enzymologyMESH
Superoxides/metabolismMESH
Tumor Cells, Cultured/enzymologyMESH
Uracil Nucleotides/pharmacologyMESH
Uridine Triphosphate/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:24 Jan 2012 13:28
Last Modified:13 Mar 2014 18:29
Item ID:23253
Owner Only: item control page

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