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Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells

Seifert, Roland and Burde, R. and Schultz, Günter (1989) Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells. Naunyn-Schmiedeberg's archives of pharmacology 340 (1), pp. 101-106.

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Abstract

There are controversial reports in the literature concerning the effects of opioids on superoxide (O2-) formation in phagocytes, these agents being either inhibitory or stimulatory. We re-examined this issue and compared the effects of the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe), phorbol myristate acetate (PMA), ATP, platelet activating factor (PAF), ...

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Item Type:Article
Date:1989
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
2552328PubMed ID
Classification:
NotationType
Adenosine Triphosphate/pharmacologyMESH
Alprostadil/pharmacologyMESH
Biotransformation/drug effectsMESH
Endorphins/pharmacologyMESH
Enkephalin, Methionine/pharmacologyMESH
HumansMESH
Leukemia, Experimental/metabolismMESH
Morphine/pharmacologyMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Naloxone/pharmacologyMESH
Neutrophils/metabolismMESH
Oxygen Consumption/drug effectsMESH
Platelet Activating Factor/pharmacologyMESH
Superoxides/metabolismMESH
Tumor Cells, Cultured/drug effectsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:24 Jan 2012 13:25
Last Modified:13 Mar 2014 18:29
Item ID:23256
Owner Only: item control page

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