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Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins

Seifert, Roland and Wenzel, Katharina and Eckstein, F. and Schultz, Günter (1989) Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. European journal of biochemistry / FEBS 181 (1), pp. 277-285.

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Abstract

Whereas the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe), induced NADPH-oxidase-catalyzed superoxide (O2-) formation in human neutrophils, purine and pyrimidine nucleotides per se did not stimulate NADPH oxidase but enhanced O2- formation induced by submaximally and maximally stimulatory concentrations of fMet-Leu-Phe up to fivefold. On the other hand, ...

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Item Type:Article
Date:1989
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
2540969PubMed ID
Classification:
NotationType
Cell AggregationMESH
Enzyme ActivationMESH
FemaleMESH
GTP-Binding Proteins/bloodMESH
Glucuronidase/bloodMESH
HumansMESH
KineticsMESH
MaleMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
NADH, NADPH Oxidoreductases/bloodMESH
NADPH OxidaseMESH
Neutrophils/physiologyMESH
Purine Nucleotides/pharmacologyMESH
Pyrimidine Nucleotides/pharmacologyMESH
Ribonucleotides/pharmacologyMESH
Structure-Activity RelationshipMESH
Superoxides/bloodMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:24 Jan 2012 13:30
Last Modified:13 Mar 2014 18:29
Item ID:23258
Owner Only: item control page
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