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The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides

Seifert, Roland and Rosenthal, W. and Schultz, Günter and Wieland, T. and Gierschick, P. and Jakobs, K. H. (1988) The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides. European journal of biochemistry / FEBS 175 (1), pp. 51-55.

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Abstract

NADPH-oxidase-catalyzed superoxide (O2-) formation in membranes of HL-60 leukemic cells was activated by arachidonic acid in the presence of Mg2+ and HL-60 cytosol. The GTP analogues, guanosine 5'-[gamma-thio]triphosphate (GTP[gamma S] and guanosine 5'-[beta,gamma-imido]triphosphate, being potent activators of guanine-nucleotide-binding proteins (G proteins), stimulated O2- formation up to ...

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Item Type:Article
Date:1988
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
2841126PubMed ID
Classification:
NotationType
Adenine Nucleotides/pharmacologyMESH
Adenosine Triphosphate/pharmacologyMESH
Arachidonic AcidMESH
Arachidonic Acids/pharmacologyMESH
Cell LineMESH
GTP-Binding Proteins/metabolismMESH
Guanine Nucleotides/pharmacologyMESH
Guanosine 5'-O-(3-Thiotriphosphate)MESH
Guanosine Diphosphate/pharmacologyMESH
Guanosine Triphosphate/pharmacologyMESH
HumansMESH
Leukemia, Myeloid, Acute/metabolismMESH
NADH, NADPH Oxidoreductases/metabolismMESH
NADPH OxidaseMESH
Phosphotransferases/metabolismMESH
Superoxides/metabolismMESH
Thionucleotides/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:26 Jan 2012 08:34
Last Modified:13 Mar 2014 18:29
Item ID:23267
Owner Only: item control page

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