Seifert, Roland and Schächtele, C.
Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase.
Biochemical and biophysical research communications 152 (2), pp. 585-592.
The effects of various protein kinase C (PKC) inhibitors on NADPH oxidase (NO) activation by the phorbol ester PMA and by the chemotactic peptide FMLP were studied. H-7 reduced the effects of both stimuli in human neutrophils (HN) and HL-60 cells by 13-63%. Polymyxin B did not inhibit NO activation by PMA and FMLP in HN and reduced the effects of both stimuli in HL-60 cells by 27-55%. Retinal and ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)|
|Enzyme Activation/drug effects||MESH|
|NADH, NADPH Oxidoreductases/metabolism||MESH|
|Protein Kinase C/physiology||MESH|
|Tumor Cells, Cultured||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
600 Technology > 615 Pharmacy
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||26 Jan 2012 08:33|
|Last Modified:||13 Mar 2014 18:29|