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Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine

Schächtele, C. and Seifert, Roland and Osswald, H. (1988) Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. Biochemical and biophysical research communications 151 (1), pp. 542-547.

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Abstract

Thrombin, 1-oleoyl-2-acetyl-rac-glycerol (OAG), cis- or trans-octadecadienoic acids (linoleic and linolelaidic acid) and the synergistic combination of octadecadienoic acids plus OAG lead to the activation of gel-filtered human platelets, i.e. aggregation via protein kinase C (PKC). Platelet activation by thrombin was only slightly suppressed by polymyxin B, ...

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Item Type:Article
Date:1988
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
2831891PubMed ID
Classification:
NotationType
1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineMESH
Alkaloids/pharmacologyMESH
Diglycerides/pharmacologyMESH
HumansMESH
Isoquinolines/pharmacologyMESH
Linoleic AcidMESH
Linoleic Acids/pharmacologyMESH
MaleMESH
Piperazines/pharmacologyMESH
Platelet Aggregation/drug effectsMESH
Platelet Aggregation Inhibitors/pharmacologyMESH
Polymyxin B/pharmacologyMESH
Polymyxins/pharmacologyMESH
Protein Kinase C/antagonists & inhibitorsMESH
StaurosporineMESH
Thrombin/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:32
Last Modified:13 Mar 2014 18:29
Item ID:23269
Owner Only: item control page

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