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Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells

Seifert, Roland and Schultz, Günter (1987) Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells. Biochemical and biophysical research communications 146 (3), pp. 1296-1302.

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Abstract

NADPH oxidase in membranes of undifferentiated and dimethylsulphoxide-differentiated HL-60 cells was activated by arachidonic acid (AA) in the presence of Mg2+ and a cytosolic cofactor (CF) found in differentiated HL-60 cells. Basal superoxide (O2-) formation was enhanced several-fold by addition of the stable GTP-analogue, guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S), prior to AA and was ...

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Item Type:Article
Date:1987
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
3113431PubMed ID
Classification:
NotationType
Cell Differentiation/drug effectsMESH
Cell LineMESH
Cell Membrane/enzymologyMESH
Dimethyl Sulfoxide/pharmacologyMESH
Edetic Acid/pharmacologyMESH
Enzyme ActivationMESH
HumansMESH
KineticsMESH
Leukemia, MyeloidMESH
Magnesium/pharmacologyMESH
NADH, NADPH Oxidoreductases/metabolismMESH
NADPH OxidaseMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:25 Jan 2012 13:49
Last Modified:13 Mar 2014 18:30
Item ID:23272
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