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Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides

Seifert, Roland and Schultz, Günter (1987) Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides. European journal of biochemistry / FEBS 162 (3), pp. 563-569.

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Abstract

Both cis and trans unsaturated fatty acids and sodium dodecyl sulfate activated NADPH oxidase in plasma membranes of human neutrophils in the presence of neutrophil cytosol. In contrast, 5,8,11,14-icosatetraynoic acid, saturated fatty acids, esters, peroxides and 4 beta-phorbol 12-myristate 13-acetate, a potent activator of protein kinase C, were inactive. 5,8,11,14-icosatetraynoic acid inhibited ...

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Item Type:Article
Date:1987
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
3549290PubMed ID
Classification:
NotationType
Cell Membrane/enzymologyMESH
Cytosol/enzymologyMESH
Drug SynergismMESH
Enzyme Activation/drug effectsMESH
Fatty Acids/pharmacologyMESH
Fatty Acids, Unsaturated/pharmacologyMESH
Guanine Nucleotides/pharmacologyMESH
Guanosine 5'-O-(3-Thiotriphosphate)MESH
Guanosine Triphosphate/pharmacologyMESH
HumansMESH
NADH, NADPH Oxidoreductases/bloodMESH
NADPH OxidaseMESH
Neutrophils/enzymologyMESH
Protein Kinase C/metabolismMESH
Sodium Dodecyl Sulfate/pharmacologyMESH
Thionucleotides/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:25 Jan 2012 13:51
Last Modified:13 Mar 2014 18:30
Item ID:23273
Owner Only: item control page

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