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Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells

Klinker, J. F. and Höer, A. and Schwaner, I. and Offermanns, S. and Wenzel-Seifert, Katharina and Seifert, Roland (1993) Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. The Biochemical journaL 296 ( Pt 1, pp. 245-251.

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Abstract

Synthetic lipopeptides activate superoxide-anion (O2-) formation in human neutrophils in a pertussis-toxin (PTX)-sensitive manner, suggesting the involvement of G-proteins of the Gi family in the signal-transduction pathway. We compared G-protein activation by lipopeptides and the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMLP) in dibutyryl-cyclic-AMP-differentiated HL-60 cells. ...

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Item Type:Article
Date:1993
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
8250850PubMed ID
Classification:
NotationType
Adenosine Diphosphate Ribose/metabolismMESH
Amino Acid SequenceMESH
Bucladesine/pharmacologyMESH
Cell Differentiation/drug effectsMESH
Cell LineMESH
GTP Phosphohydrolases/metabolismMESH
GTP-Binding Proteins/metabolismMESH
Guanosine Triphosphate/metabolismMESH
HumansMESH
KineticsMESH
Leukemia, Promyelocytic, AcuteMESH
Lipoproteins/pharmacologyMESH
Membrane Proteins/metabolismMESH
Molecular Sequence DataMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Neutrophils/metabolismMESH
Pertussis ToxinMESH
Superoxides/metabolismMESH
Time FactorsMESH
Tumor Cells, CulturedMESH
Virulence Factors, Bordetella/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:25 Jan 2012 13:56
Last Modified:13 Mar 2014 18:30
Item ID:23287
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