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Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations

Wenzel-Seifert, Katharina and Seifert, Roland (1993) Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. Naunyn-Schmiedeberg's archives of pharmacology 348 (1), pp. 7-13.

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Abstract

The macrolide, FK-506, is a potent and effective inhibitor of lymphocyte activation. We studied the effects of FK-506 on human neutrophil activation induced by chemoattractants and by various substances which circumvent receptor stimulation. After preincubation for 5 min at 37 degrees C, FK-506 (1 microM) inhibited N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe)- or ...

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Item Type:Article
Date:1993
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
7690907PubMed ID
Classification:
NotationType
AdultMESH
Calcimycin/pharmacologyMESH
Calcium/metabolismMESH
Cyclosporine/pharmacologyMESH
Dose-Response Relationship, DrugMESH
FemaleMESH
HumansMESH
Leukemia, Promyelocytic, Acute/pathologyMESH
MaleMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Neutrophils/metabolismMESH
Superoxides/metabolismMESH
Tacrolimus/pharmacologyMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:25 Jan 2012 10:40
Last Modified:13 Mar 2014 18:30
Item ID:23288
Owner Only: item control page
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