Wenzel-Seifert, Katharina and Seifert, Roland
Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations.
Naunyn-Schmiedeberg's archives of pharmacology 348 (1), pp. 7-13.
The macrolide, FK-506, is a potent and effective inhibitor of lymphocyte activation. We studied the effects of FK-506 on human neutrophil activation induced by chemoattractants and by various substances which circumvent receptor stimulation. After preincubation for 5 min at 37 degrees C, FK-506 (1 microM) inhibited N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe)- or ...
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