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Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E

Wenzel-Seifert, Katharina and Seifert, Roland (1993) Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. The Journal of Immunology 150 (10), pp. 4591-4599.

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Abstract

The cyclic undecapeptide, cyclosporin (Cs) H, is a potent inhibitor of FMLP-induced superoxide anion (O2-) formation in human neutrophils. We studied the effects of CsH in comparison with those of N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L- phenylalanine (BocPLPLP), a well known formyl peptide receptor antagonist, and of other Cs on activation of N6,2'-O-dibutyryl ...

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Item Type:Article
Date:1993
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
8387097PubMed ID
Classification:
NotationType
Amino Acid SequenceMESH
Bucladesine/pharmacologyMESH
Cell Differentiation/drug effectsMESH
Cell Membrane/metabolismMESH
CyclosporineMESH
Cyclosporins/pharmacologyMESH
Glucuronidase/metabolismMESH
HumansMESH
Molecular Sequence DataMESH
N-Formylmethionine Leucyl-Phenylalanine/metabolismMESH
Oligopeptides/pharmacologyMESH
Receptors, Formyl PeptideMESH
Receptors, Immunologic/antagonists & inhibitorsMESH
Superoxides/metabolismMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:25 Jan 2012 13:57
Last Modified:13 Mar 2014 18:30
Item ID:23289
Owner Only: item control page

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