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Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C

Wenzel-Seifert, K. and Schächtele, C. and Hummel, R. and Grünbaum, L. and Seifert, Roland (1994) Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. Biochemical pharmacology 48 (5), pp. 859-864.

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Abstract

Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages. We found that CsA inhibited O2- formation in HL-60 cells induced by PMA (30 nM) and phorbol dibutyrate (200 nM) with a half-maximal effect at 1 and 0.75 microM, respectively. One possible target of CsA action is protein kinase C ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
8093097PubMed ID
Classification:
NotationType
AnimalsMESH
Cell Differentiation/drug effectsMESH
Cells, CulturedMESH
Cyclosporine/pharmacologyMESH
HumansMESH
MiceMESH
Neutrophils/metabolismMESH
Phagocytes/metabolismMESH
Platelet Aggregation/drug effectsMESH
Protein Kinase C/antagonists & inhibitorsMESH
RatsMESH
Superoxides/metabolismMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:25
Last Modified:13 Mar 2014 18:30
Item ID:23296
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