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Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores

Seifert, Roland and Grünbaum, L. and Schultz, Günter (1994) Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores. Naunyn-Schmiedeberg's archives of pharmacology 349 (4), pp. 355-361.

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Abstract

The results of binding studies suggest the presence of histamine H1-receptors in human monocytes, but it is not known whether these receptors are functionally active. This prompted us to study the effects of histamine (HA) on cytosolic Ca2+ concentration ([Ca2+]i) and superoxide anion (O2-) formation in HL-60 cells differentiated towards monocytes with 1 alpha,25-dihydroxycholecalciferol. In ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
8058107PubMed ID
Classification:
NotationType
Adenosine Diphosphate Ribose/metabolismMESH
Calcium/metabolismMESH
Cell LineMESH
GTP-Binding Proteins/metabolismMESH
Histamine/pharmacologyMESH
Histamine Agonists/pharmacologyMESH
HumansMESH
Imidazoles/pharmacologyMESH
Monocytes/metabolismMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Oxygen Consumption/drug effectsMESH
Pertussis ToxinMESH
Platelet Aggregation Inhibitors/pharmacologyMESH
Receptors, Histamine H1/metabolismMESH
Virulence Factors, Bordetella/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:18
Last Modified:13 Mar 2014 18:30
Item ID:23301
Owner Only: item control page
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