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The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes

Seifert, Roland and Hagelüken, A. and Höer, A. and Höer, D. and Grünbaum, L. and Offermanns, S. and Schwaner, I. and Zingel, V. and Schunack, W. and Schultz, Günter (1994) The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. Molecular Pharmacology 45 (4), pp. 578-586.

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Abstract

In dibutyryl-cAMP-differentiated HL-60 cells, histamine H1 and formyl peptide receptors mediate increases in the cytosolic Ca2+ concentration ([Ca2+]i) via pertussis toxin-sensitive G proteins of the Gi family. We compared the effects of 2-(3-chlorophenyl)-histamine (CPH) [2-[2-(3-chlorophenyl)-1H-imidazol-4-yl] ethanamine], one of the most potent and selective H1 receptor agonists presently ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
7514261PubMed ID
Classification:
NotationType
Calcium/metabolismMESH
Cell Membrane/drug effectsMESH
Enzyme Activation/drug effectsMESH
GTP-Binding Proteins/metabolismMESH
Glucuronidase/metabolismMESH
GlycerophospholipidsMESH
Guanosine Triphosphate/metabolismMESH
Histamine/pharmacologyMESH
Histamine Agonists/pharmacologyMESH
HumansMESH
L-Lactate Dehydrogenase/metabolismMESH
Manganese/metabolismMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Pertussis ToxinMESH
Phosphatidic Acids/metabolismMESH
Phosphatidylinositols/metabolismMESH
PhosphotyrosineMESH
Receptors, Histamine H1/drug effectsMESH
Respiratory Burst/drug effectsMESH
Superoxides/metabolismMESH
Tumor Cells, CulturedMESH
Tyrosine/metabolismMESH
Virulence Factors, Bordetella/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:19
Last Modified:13 Mar 2014 18:30
Item ID:23302
Owner Only: item control page

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