Naim, M. and Seifert, Roland and Nürnberg, B. and Grünbaum, L. and Schultz, Günter
Some taste substances are direct activators of G-proteins.
The Biochemical journal 297 ( Pt 3, pp. 451-454.
Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that amphiphilic taste substances may elicit taste through direct activation of G-proteins.