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Some taste substances are direct activators of G-proteins

Naim, M. and Seifert, Roland and Nürnberg, B. and Grünbaum, L. and Schultz, Günter (1994) Some taste substances are direct activators of G-proteins. The Biochemical journal 297 ( Pt 3, pp. 451-454.

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Abstract

Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
8110180PubMed ID
Classification:
NotationType
AnimalsMESH
CattleMESH
Enzyme ActivationMESH
GTP Phosphohydrolases/metabolismMESH
GTP-Binding Proteins/metabolismMESH
PeptidesMESH
PhosphatidylcholinesMESH
Phospholipids/pharmacologyMESH
Sweetening Agents/pharmacologyMESH
Taste/drug effectsMESH
Wasp Venoms/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 08:17
Last Modified:13 Mar 2014 18:30
Item ID:23303
Owner Only: item control page

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