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Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors

Musgrave, I. F. and Seifert, Roland (1994) Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors. Biochemical pharmacology 47 (2), pp. 233-239.

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Abstract

Human neutrophils have been reported to possess both alpha 2- and beta 2-adrenoceptors. While activation of beta 2-adrenoceptors is known to inhibit N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2-) production, the functional role of alpha 2-adrenoceptors is not known. We studied the effects of a range of structurally unrelated alpha 2-adrenoceptor agonists on ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
7905732PubMed ID
Classification:
NotationType
Adrenergic alpha-Agonists/pharmacologyMESH
Azepines/pharmacologyMESH
Dioxanes/pharmacologyMESH
GTP Phosphohydrolases/metabolismMESH
HumansMESH
Idazoxan/analogs & derivativesMESH
Isoproterenol/pharmacologyMESH
N-Formylmethionine Leucyl-PhenylalanineMESH
Neutrophils/metabolismMESH
Quinoxalines/pharmacologyMESH
Receptors, Adrenergic, alpha/drug effectsMESH
Superoxides/analysisMESH
TritiumMESH
Tumor Cells, Cultured/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jan 2012 07:30
Last Modified:13 Mar 2014 18:30
Item ID:23304
Owner Only: item control page
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